Summary:
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Breast cancer is one of the most diagnosed cancers among women in the United States – Women have nearly a 12.8% lifetime risk of developing breast cancer.
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Current treatments for breast cancer include surgery, radiation, and chemotherapy. Adjuncts to these methods have been developed to improve the clinical outcomes for patients.
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One such adjunctive treatment is mild hyperthermia therapy (MHTh), which has been shown to be successful in treating cancers by increasing effectiveness and reducing dosage requirements for radiation and chemotherapies.
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Existing MHTh systems typically use MRI for thermometry and radiofrequency, microwaves, or FUS for heat induction. However, this leads to a complex, expensive, and inaccessible therapy platform.
Our research looks to develop an ultrasound tomography (UST) based MHTh system where sound speed measurements are used for thermometry and focused ultrasound (FUS) for heat induction.
Reference:
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Bustamante, D., Yan Y., Mitcham T., Duric N., Mehrmohammadi M. (2024) The efficacy of an ultrasound ring-array transducer for hyperthermia generation. Medical Imaging: Ultrasonic Imaging and Tomography
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Pattyn, A., Kratkiewicz, K., Alijabbari, N., Carson, P. L., Littrup, P., Fowlkes, J. B., ... & Mehrmohammadi, M. (2022). Feasibility of ultrasound tomography–guided localized mild hyperthermia using a ring transducer: Ex vivo and in silico studies. Medical Physics.
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Pattyn, Alexander, Naser Alijabbari, and Mohammad Mehrmohammadi. "Fluence Compensation for Improving Quantitative Photoacoustic Spectroscopy." 2020 IEEE International Ultrasonics Symposium (IUS). IEEE, 2020.